Improving deformable image registration with point metric and masking technique for postoperative breast cancer radiotherapy

摘要

Deformable image registration (DIR) is increasingly used for target volume definition in radiotherapy. However, this method is challenging for postoperative breast cancer patients due to the large deformations and non-correspondence caused by tumor resection and clip insertion. In this study, an improved B-splines based DIR method was developed to address this issue for higher registration accuracy.