Utility of perfusion decellularization to achieve biochemical and mechanically accurate whole animal and organ‐specific tissue scaffolds

摘要

Due to the limited supply of donor organs and the need for new sources of replacement tissue, researchers continue to strive for new ways to engineer partial and whole organ replacements. A key step is to recreate the 3‐dimensional (3D) architecture using extracellular matrix (ECM)—with tissue‐specific composition—to provide the mechanical and biochemical cues required to promote tissue development. To address the challenge of creating 3D tissue scaffolds, the field has turned toward tissue decellularization as a source for tissue‐specific ECM and as a way of obtaining a cell‐free scaffold for tissue engineering and regenerative medicine.