Eye movements in patients in early psychosis with and without a history of cannabis use

摘要

a In the decreased vulnerability model, cannabis represents a distinct risk factor and less heritable predisposition to schizophrenia is required to reach the psychotic threshold. If oculomotor deficits represent a heritable endophenotype for schizophrenia, we would expect impairment in EPNC vs EPC. b In the shared vulnerability model there is no difference in heritable component of EPC vs EPNC and we would not expect to see any oculomotor difference in EPC vs EPNC. EPC early psychosis with cannabis use, EPNC early psychosis without cannabis use, HCC healthy controls with cannabis use, HCNC healthy controls without cannabis use, SPEM smooth pursuit eye movements, AS antisaccades.