O3.7. SMOOTH PURSUIT EYE MOVEMENTS INDICATE BIOLOGICAL DISTINCTION BETWEEN CANNABIS-USING AND NON-USING PATIENTS IN EARLY PSYCHOSIS

摘要

Oculomotor abnormalities are among the most widely replicated findings in psychotic disorders with impairments in Smooth Pursuit Eye Movements (SPEM) and Antisaccades (AS) tasks. Cannabis-use may be a clinically relevant demarcating factor in early psychosis seen in around half of FEP patients at presentation and indicative of worse prognosis. No study to date has aimed at differentiating cannabis-using from non-using patients using AS and SPEM. Differences in eye movement measures between groups would indicate altered neurobiology between cannabis-using and non-using patients. We thus aimed to determine whether abnormalities in SPEM and AS are indicative of neurobiological differences between Early Psychosis patients who use cannabis (EPC) and those who do not use cannabis (EPNC).