a Representative axial slices of T1-weighted MRI after contrast administration and (b) T2-weighted FLAIR obtained prior to stereotactic brain biopsy show a predominantly non-enhancing lesion within the deep right parietal lobe with small areas of patchy enhancement that is crossing the corpus callosum with associated edema. Repeat imaging obtained nearly 2 years after biopsy and completion of adjuvant chemoradation demonstrates (c) stable foci of small nodular enhancement on T1-weighted MRI after contrast administration with (d) minimal associated edema on T2-weighted FLAIR. e, f An infiltrating astrocytoma without necrosis or vascular proliferation is seen on hematoxylin & eosin staining. g Immunohistochemistry for GFAP-positive tumor cells is shown and (h) the Ki-67 proliferative index was ~3%.
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