The Relationship Between Functional Dyspepsia PPI Therapy and the Gastric Microbiome

摘要

Dyspepsia refers to symptoms originating from the gastroduodenal region and includes etiologies such as gastroesophageal reflux, hiatal hernias, peptic ulcers, H. pylori infections, erosive gastritis, and gastroesophageal malignancy.1,2 Symptomology often varies, but may include nausea, vomiting, heartburn, dysphagia, and chest pain. Dyspepsia affects about 40% of the general population and etiologies often can be diagnosed with the use of esophagogastro-duodenoscopy (EGD).3 Despite the use of EGDs, 70% of patients diagnosed with dyspepsia are negative for any structural or infectious (i.e., H. pylori) etiology.4 In such patients, the diagnosis of functional dyspepsia (FD) often is made.