Homoharringtonine inhibits fibroblasts proliferation extracellular matrix production and reduces surgery-induced knee arthrofibrosis via PI3K/AKT/mTOR pathway-mediated apoptosis

摘要

Histological analysis images of intraarticular fibrosis tissue. a Loose or thin fibrosis scar tissues with few adhesions to bone cortex were found in 0.2 mg/ml HHT-treated group. Moderate fibrosis scar tissues with slight adherence to bone cortex were found in 0.1 mg/ml HHT-treated group. Dense or thick fibrosis scar tissues with extensive or firm adherence to bone cortex were found in control group. All sections were stained by the mean of H&E, and the magnification was × 40. b In vivo, the images of fibroblasts in intraarticular fibrosis scar tissues of each group. The magnification was × 200. Three counting areas were selected from every section to calculate fibroblast number. *P < 0.05 versus the control group