Neutrophils are key cells in host defense, playing a broad range of roles, and we would not stay alive in their absence [1, 2, 3, 4, 5, 6]. Thus, impaired effector functions of these cells, as exemplified by chronic granulomatous disease, may result in significant immunodeficiencies [7]. The actin cytoskeleton plays important roles in the functions of neutrophils, and mutations can result in impaired motility, signaling, proliferative capacity, and defective antimicrobial host defense. In an excellent and comprehensive review, Evelien Sprenkeler, Steven Webbers, and Taco Kuijpers describe what is known with respect to the effect of these mutations on human neutrophil function [8].
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