The Relationship between Neonatal Transient Tachypnea and Maternal Disease in Newborns

摘要

Transient tachypnea of the newborn (TTN) is known as a clinical self-limited tachypnea syndrome caused by delayed clearance of fetal lung fluid. While the exact incidence is probably under-reported, it is estimated at 3–6 per 1,000 term newborn births, making TTN the most common etiology of tachypnea in the newborn (1). Infancy is a very vulnerable time for a baby completing and regulating many of the physiological mechanisms necessary for extra uterine life (2). The most important differential diagnosis of TTN is the Respiratory Distress Syndrome (RDS). RDS is caused by inadequate production of pulmonary surfactant and it is a major cause of morbidity and mortality in preterm infants. The incidence of RDS increases with decreasing gestational age, and infants born before 30 weeks of gestation are at the greatest risk. Furthermore, > 40% of pre-term deliveries result in TTN due to the delayed absorption and clearance of fetal alveolar fluid. While TTN has been limited spontaneously within 48–72 hours after birth (3).