3PC-014 Stability study of gentamicin lock therapy with heparin or citrate as anticoagulant

摘要

The antibiotic lock therapy (ALT) technique that involves the instillation of a highly concentrated antimicrobial solution with additives such as anticoagulants into the catheter lumen, is an option for treatment of catheter-related bloodstream infections when the central venous catheter is retained. An important limitation is the frequent incompatibility between the components, causing great controversy in the literaure. The ALT with gentamicin is one of the most requested ALT for treating bacteriemias by Gram(-). The anticoagulant that is studied more is unfractioned heparin. It can be used in haemodialysis patients, however, other anticoagulants such as citrate whose data are limited regarding compatibility should be used for patients with a history of heparin-induced trombocytopenua (HIT) or active HIT.