Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling

摘要

CNFs and PNFs are epigenetically distinct tumor types. a Clinical presentation of a CNF with H/E stain (20X/100X magnification shown); versus b PNF resected from deep shoulder location (T2-weighted MRI image; H/E 20X/100X shown). c Principal component analysis of RNAseq expression data comparing CNFs (purple) and PNFs (green) neurofibromas. d Copy number analysis of CNFs versus PNFs. e Unsupervised hierarchical cluster analysis of methylation probesets (i.e., beta-values) demonstrating unique CNF and PNF methylation profiles