Charge-Transfer Complex of Linifanib with 23-dichloro-35-dicyano-14-benzoquinone: Synthesis Spectroscopic Characterization Computational Molecular Modelling and Application in the Development of Novel 96-microwell Spectrophotometric Assay

摘要

Linifanib (LFB) is a multi‐targeted receptor tyrosine kinase inhibitor used in the treatment of hepatocellular carcinoma and other types of cancer. The charge-transfer (CT) interaction of LFB is important in studying its receptor binding mechanisms and useful in the development of a reliable CT-based spectrophotometric assay for LFB in its pharmaceutical formulation to assure its therapeutic benefits.