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Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label Phase 1 clinical trial

机译：INO-4800 DNA疫苗对SARS-COV-2的安全性和免疫原性：开放标签第1期临床试验的初步报告

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摘要

A vaccine against SARS-CoV-2 is of high urgency. Here the safety and immunogenicity induced by a DNA vaccine (INO-4800) targeting the full length spike antigen of SARS-CoV-2 are described.

机译：针对SARS-COV-2的疫苗具有高急使。这里描述了靶向SARS-COV-2的全长尖峰抗原的DNA疫苗（INO-4800）诱导的安全性和免疫原性。

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期刊名称 EClinicalMedicine
作者
Pablo Tebas; ShuPing Yang; Jean D. Boyer; Emma L. Reuschel; Ami Patel; Aaron Christensen-Quick; Viviane M. Andrade; Matthew P. Morrow; Kimberly Kraynyak; Joseph Agnes; Mansi Purwar; Albert Sylvester; Jan Pawlicki; Elisabeth Gillespie; Igor Maricic; Faraz I. Zaidi; Kevin Y. Kim; Yaya Dia; Drew Frase; Patrick Pezzoli; Katherine Schultheis; Trevor R.F. Smith; Stephanie J. Ramos; Trevor McMullan; Karen Buttigieg; Miles W. Carroll; John Ervin; Malissa C. Diehl; Elliott Blackwood; Mammen P. Mammen; Jessica Lee; Michael J. Dallas; Ami Shah Brown; Jacqueline E. Shea; J.Joseph Kim; David B. Weiner; Kate E. Broderick; Laurent M. Humeau;
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年(卷),期 2021(-1),-1
年度 2021
页码 -1
总页数 9
原文格式 PDF
正文语种
中图分类
关键词
SARS-CoV-2; COVID-19; DNA vaccine; INO-4800; Phase 1;

机译：说 - 杯2;Kovid -19;DNA Vaqin;INO-4800;面部1;

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1. Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial [J] . Cristina Carter, Katherine V. Houser, Galina V. Yamshchikov, PLoS One . 2019,第9期

机译：调查季节性流感血凝素DNA疫苗的安全性和免疫原性，然后是在健康成人的皮内或肌肉内施用的三价灭活疫苗：开放式随机阶段1临床试验
2. Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials [J] . Gaudinski Martin R., Houser Katherine V., Morabito Kaitlyn M., The Lancet . 2018,第10120期

机译：两种Zika病毒DNA疫苗候选的安全性，耐受性和免疫原性在健康成人中：随机，开放标签，第1期临床试验
3. Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial [J] . Modjarrad Kayvon, Roberts Christine C., Mills Kristin T., The Lancet infectious diseases . 2019,第9期

机译：抗中东呼吸综合征冠状病毒DNA疫苗的安全性和免疫原性：1相，开放标签，单臂，剂量升级试验
4. A double-blind, randomized phase II trial of thesafety and immunogenicity of 26-valent group A streptococcus vaccine in healthy adults [C] . Shelly A. McNeil, Scott A. Halperin, Joanne M. Langley, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：一种双盲，随机期II试验，对健康成人的26岁的26岁群体的疫苗疫苗
5. Efficacy and safety of novel collagen conduits filled with collagen filaments to treat patients with peripheral nerve injury: A multicenter, controlled, open-label clinical trial [D] . Saeki Masaomi, 佐伯将臣 2019

机译：充满胶原细丝的新型胶原蛋白导管治疗周围神经损伤患者的疗效和安全性：一项多中心，对照，开放标签的临床试验
6. Safety and Immunogenicity of a DNA SARS-CoV-2 vaccine (ZyCoV-D): Results of an open-label non-randomized phase I part of phase I/II clinical study by intradermal route in healthy subjects in India [O] . Taufik Momin, Kevinkumar Kansagra, Hardik Patel, 2021

机译：DNA SARS-COV-2疫苗（ZYCOV-D）的安全性和免疫原性：在印度健康受试者中在印度的健康受试者中内部I / II临床研究的开放标签非随机阶段I部分的结果
7. Safety and immunogenicity of a recombinant DNA COVID-19 vaccine containing the coding regions of the spike and nucleocapsid proteins: Preliminary results from an open-label, phase 1 trial in healthy adults aged 19–55 years [O] . Jin Young Ahn, Jeongsoo Lee, You Suk Suh, 2021

机译：重组DNA Covid-19疫苗的安全性和免疫原性，含有穗和核衣壳的编码区：19-55岁的健康成年人的开放标签，第1期试验的初步结果

Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label Phase 1 clinical trial

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