Significance of mesothelin and CA125 expression in endometrial carcinoma: a retrospective analysis

摘要

The expression variation of mesothelin and cancer antigen (CA) 125. a Mesothelin-positive cells in grade 1 endometrioid carcinoma. The percentage of mesothelin-positive cells is ≥50% (tumor proportion score: 3+), and the entire circumference of the cancer cell membrane is stained (intensity score: 2+). b CA125-positive cells of grade1, endometrioid carcinoma. The percentage of CA125-positive cells is ≥50% (proportion score: 3+), and the cytoplasm of cancer cell is highly stained (intensity score: 2+). c Mesothelin-positive cells in grade 2 endometrioid carcinoma. The percentage of mesothelin-positive cells is ≥50% (tumor proportion score: 3+), and the entire circumference of the cancer cell membrane is stained (intensity score: 2+). d CA125-positive cells of grade2, endometrioid carcinoma. The percentage of CA125-positive cells is ≥50% (proportion score: 3+), and the cytoplasm of cancer cell is highly stained (intensity score: 2+). e Mesothelin-positive cells in grade 3 endometrioid carcinoma. The percentage of mesothelin-positive cells is ≥50% (tumor proportion score: 3+), and the entire circumference of the cancer cell membrane is stained (intensity score: 2+). f CA125-positive cells of grade3, endometrioid carcinoma. The percentage of CA125-positive cells is ≥50% (proportion score: 3+), and the cytoplasm of cancer cell is highly stained (intensity score: 2+). g Mesothelin-negative cells in grade 1 endometrioid carcinoma. No staining is noted in the cancer cell’s membrane. h CA125-negative cells in grade 1 endometrioid carcinoma. No staining is noted in the cancer cell’s membrane. Magnification for all slides: × 100. *HE, hematoxylin-eosin