The skin is the outermost protective organ susceptible to damage by external injury and retains undesired scars after wound healing, which often diminishes the quality of life and causes economic burden. Periostin, an extracellular matrix component, is reportedly closely associated with skin wound healing and pathologic scar formation. It is expressed in various normal tissues, often associated with fibroblasts, and involved in remodeling of the extracellular matrix environment.[1,2] In some disease states, such as myocardial infarction, cancer, liver fibrosis, and pathologic scarring of the skin, periostin is reportedly a vital regulator of the progression of the disease and significantly over-expressed.[3] This article summarizes recent advancements in studies on the role of periostin in skin wound healing and pathologic scar formation.
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