Hypoxia induces sorafenib resistance mediated by autophagy via activating FOXO3a in hepatocellular carcinoma

摘要

A Detection of relative cell viability of HCC cells (Huh-7, LM-3, SNU-387, and SNU-449) cultured in normoxia and hypoxia (Control vs. Hypoxia, ***p < 0.001, **p < 0.01; two-way ANOVA). B Detection of proliferative viability of sorafenib-treated HCC cells (Huh-7, LM-3, SNU-387, and SNU-449) cultured in normoxia and hypoxia (Sorafenib vs. Sorafenib+Hypoxia, ***p < 0.001; t-test). Each experiment was performed in quintuplicate (N = 5). The data are presented as the means ± SD.