Validation of the 8th Edition American Joint Commission on Cancer (AJCC) Gallbladder Cancer Staging System: Prognostic Discrimination and Identification of Key Predictive Factors

摘要

Despite implementing numerous changes in the American Joint Committee on Cancer (AJCC) staging system for gallbladder cancer (GBC), the ability to accurately prognosticate survival in these patients has not been vigorously evaluated. The purpose of our study was to compare the prognostic ability of AJCC 7th and 8th edition, investigate the effect of AJCC 8th edition nodal status on the survival, and identify risk factors associated with the survival after N reclassification in GBC patients. We used the largest cancer database in the United States and determined that the updated AJCC 8th edition GBC staging system was comparable to the 7th edition, with no major improvements in survival discrimination. The recently implemented changes in N classification do not appear to improve the prognostic performance of the AJCC cancer staging system with regard to survival in GBC patients.