Topical co‐administration of zoledronate with recombinant human bone morphogenetic protein-2 can induce and maintain bone formation in the bone marrow environment

摘要

Representative photos of the left distal femurs of rabbits cut in the sagittal plane at 3 and 6 weeks after implantation. In the images, the left side is distal side of femur and the upper side is dorsal side of femur. Arrows point to a section of the edge of the implanted β-TCP. The gross appearances of implanted β-TCP columns gradually disappeared (a). The gross appearances of β-TCP columns in groups containing ZOL (f and h) were comparatively more recognizable than in the other groups without ZOL (b and d) at 6 weeks after implantation