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Mild hypothermia improves brain injury in rats with intracerebral hemorrhage by inhibiting IRAK2/NF‐κB signaling pathway

机译：通过抑制伊拉克2 / NF-κB信号通路温和的体温过低提高脑内出血大鼠脑损伤

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摘要

To explore the effect of mild hypothermia on nerve injury by establishing a rat model of intracerebral hemorrhage (ICH), and to clarify the specific molecular mechanism of mild hypothermia in improving brain injury in ICH rats.

机译：通过建立脑出血（ICH）大鼠模型，探讨轻度体温过低对神经损伤的影响，并阐明了轻度体温过低的特定分子机制改善ICH大鼠脑损伤的特定分子机制。

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期刊名称 Brain and Behavior
作者
Hui Shi; Zulu Su; Hai Su; Hao Chen; Yi Zhang; Yuan Cheng;
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作者单位

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年(卷),期 2021(11),1
年度 2021
页码 e01947
总页数 9
原文格式 PDF
正文语种
中图分类医学行为学;
关键词
apoptosis; brain injury; intracerebral hemorrhage; IRAK2/NF‐κB pathway; mild hypothermia;

机译：细胞凋亡;脑损伤;脑出血;伊拉克2 / NF-κB途径;轻度体温过低;

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专利

1. Mild hypothermia protects against early brain injury in rats following subarachnoid hemorrhage via the TrkB/ERK/CREB signaling pathway [J] . Lv Ou, Zhou Fenggang, Zheng Yongri, Molecular medicine reports . 2016,第4aPta1期

机译：轻度亚低温可通过TrkB / ERK / CREB信号通路防止蛛网膜下腔出血对大鼠的早期脑损伤
2. Mild hypothermia protects against early brain injury in rats following subarachnoid hemorrhage via the TrkB/ERK/CREB signaling pathway [J] . Lv Ou, Zhou Fenggang, Zheng Yongri, Molecular medicine reports . 2016,第4aPta2期

机译：通过TRKB / ERK / CREB信号通路在蛛网膜下腔出血之后，轻度体温过低保护大鼠的早期脑损伤
3. Pentoxifylline Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats: Possibly via Inhibiting TLR 4/NF-kappa B Signaling Pathway [J] . Xia Da-yong, Zhang Hua-sheng, Wu Ling-yun, Neurochemical research . 2017,第4期

机译：Pentoxificlline减轻了大鼠实验性蛛网膜下腔出血后的早期脑损伤：可能通过抑制TLR 4 / NF-Kappa B信号通路
4. THEORETICAL SIMULATION OF TEMPERATURE DISTRIBUTION IN THE BRAIN DURING MILD HYPOTHERMIA TREATMENT FOR BRAIN INJURY [C] . Liang Zhu, Chenguang Diao National heat transfer conference;NHTC2001 . 2001

机译：轻度低温治疗脑损伤过程中脑内温度分布的理论模拟
5. Neuroprotective efficacy of minocycline after intracerebral hemorrhage and possible Kv1.3, Kv1.5, HERG and alpha7 nAChR channels as targets for regulating secondary brain injury in hemorrhagic and ischemic stroke. [D] . Yerneni, Tejaswi. 2005

机译：脑出血后米诺环素的神经保护功效以及可能的Kv1.3，Kv1.5，HERG和alpha7 nAChR通道作为调节出血性和缺血性中风继发性脑损伤的靶标。
6. Sodium Benzoate Attenuates Secondary Brain Injury by Inhibiting Neuronal Apoptosis and Reducing Mitochondria-Mediated Oxidative Stress in a Rat Model of Intracerebral Hemorrhage: Possible Involvement of DJ-1/Akt/IKK/NFκB Pathway [O] . Weilin Xu, Tao Li, Liansheng Gao, 2019

机译：苯甲酸钠通过抑制神经元凋亡和减少线粒体介导的氧化应激在大鼠脑出血模型中减轻继发性脑损伤：可能涉及DJ-1 / Akt / IKK /NFκB途径
7. Mild hypothermia improves brain injury in rats with intracerebral hemorrhage by inhibiting IRAK2/NF‐κB signaling pathway [O] . Hui Shi, Zulu Su, Hai Su, 2020

机译：通过抑制伊拉克2 / NF-κB信号通路，温和的体温过低提高脑内出血大鼠脑损伤

Mild hypothermia improves brain injury in rats with intracerebral hemorrhage by inhibiting IRAK2/NF‐κB signaling pathway

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