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Safety and pharmacokinetic profiles of MGS0274 besylate (TS‐134) a novel metabotropic glutamate 2/3 receptor agonist prodrug in healthy subjects

机译：MgS0274 BERYLATE（TS-134）的安全性和药代动力学谱新型代谢谷氨酸2/3受体激动剂前药健康受试者

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摘要

The safety and pharmacokinetics of single and multiple doses of a novel mGlu2/3 receptor agonist prodrug, MGS0274 besylate (TS‐134), were investigated in healthy subjects.

机译：在健康受试者中研究了单一和多剂量的单一和多剂量的单剂和多剂量的单剂和多剂量的MgS0274苯磺酸盐（TS-134）。

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期刊名称 British Journal of Clinical Pharmacology
作者
Mai Watanabe; Brian Marcy; Kohnosuke Kinoshita; Misako Fukasawa; Hirohiko Hikichi; Shigeyuki Chaki; Shigeru Okuyama; Hakop Gevorkyan; Shigeru Yoshida;
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作者单位

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年(卷),期 2020(86),11
年度 2020
页码 2286–2301
总页数 16
原文格式 PDF
正文语种
中图分类药学;
关键词
cerebrospinal fluid; mGlu;

机译：脑脊液;mglu;

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专利

1. Safety and pharmacokinetic profiles of MGS0274 besylate (TS-134), a novel metabotropic glutamate 2/3 receptor agonist prodrug, in healthy subjects [J] . Watanabe Mai, Marcy Brian, Kinoshita Kohnosuke, British Journal of Clinical Pharmacology . 2020,第11期

机译：MgS0274 BESYLINATE（TS-134）的安全性和药代动力学谱，新型代谢谷氨酸2/3受体激动剂前药，健康受试者
2. Safety and pharmacokinetic profiles of MGS0274 besylate (TS‐134), a novel metabotropic glutamate 2/3 receptor agonist prodrug, in healthy subjects [J] . Mai Watanabe, Brian Marcy, Kohnosuke Kinoshita, British journal of clinical pharmacology . 2020,第11期

机译：MgS0274 BERYLATE（TS-134）的安全性和药代动力学谱，新型代谢谷氨酸2/3受体激动剂前药，健康受试者
3. Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia [J] . Kohnosuke Kinoshita, Motoki Ochi, Katsuya Iwata, Pharmacology Research & Perspectives . 2019,第5期

机译：MgS0274的临床前置位，一种高效族代谢谷氨酸受体激动剂MGS0008用于治疗精神分裂症的前药
4. Inverse agonists to explore the mechanisms of metabotropic glutamate receptor activity [C] . L. Prezeau, M.L. Parmentier, R Carroll, Fundaci髇 Dr. Antonio Esteve . 2003

机译：反向激动剂探讨代谢谷氨酸受体活性的机制
5. Metabotropic Glutamate Receptors Effects on Feeding [D] . Cano, Jonathan Rene Charles 2015

机译：代谢型谷氨酸受体对饲料的影响
6. Preclinical disposition of MGS0274 besylate a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia [O] . Kohnosuke Kinoshita, Motoki Ochi, Katsuya Iwata, 2019

机译：MGS0274苯磺酸盐的临床前处置它是强效的II型代谢型谷氨酸受体激动剂MGS0008的前药用于治疗精神分裂症
7. Safety and pharmacokinetic profiles of MGS0274 besylate (TS‐134), a novel metabotropic glutamate 2/3 receptor agonist prodrug, in healthy subjects [O] . Mai Watanabe, Brian Marcy, Kohnosuke Kinoshita, 2020

机译：MgS0274 BERYLATE（TS-134）的安全性和药代动力学谱，新型代谢谷氨酸2/3受体激动剂前药，健康受试者

Safety and pharmacokinetic profiles of MGS0274 besylate (TS‐134) a novel metabotropic glutamate 2/3 receptor agonist prodrug in healthy subjects

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