Neurodevelopmental Defects: A Micropatterned Human‐Specific Neuroepithelial Tissue for Modeling Gene and Drug‐Induced Neurodevelopmental Defects (Adv. Sci. 5/2021)

摘要

In article number 2001100, Yi‐Chin Toh and co‐workers combine hPSC micropatterning and a temporally‐sequenced induction protocol to specify neuroepithelial (NE) cells in spatial juxtaposition to mesoendoderm cells. This results in the formation of a reproducible and highly‐organized NE tissue. By evaluating NE tissue structural dysmorphia in the micropatterned NE model, gene‐ and drug‐induced neurodevelopmental defects can be successfully modelled.