Perspective on therapeutic and diagnostic potential of camel nanobodies for coronavirus disease-19 (COVID-19)

摘要

Schematic representation of the origin of COVID-19 cytokine storm. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters cells via binding to angiotensin-converting enzyme 2 receptor (ACE2). The rapid viral replication in the first infection stage leads to an inflammatory response and provokes an accumulation of large amounts of pro-inflammatory cytokines referred as cytokine storm (