Distribution of marbofloxacin within the bronchoalveolar region of healthypigs

摘要

The purpose of this study was to clarify the distribution of marbofloxacin (MBFX) withinthe bronchoalveolar region of pigs. Four clinically healthy pigs were intramuscularlyinjected with a single dose of MBFX (2 mg/kg). Samples of plasma and bronchoalveolarlavage fluid (BALF) were obtained for each pig at 0 (before administration), 3, 8 and 24hr after administration of MBFX. As a result, the MBFX concentrations in pulmonaryepithelial lining fluid (ELF) and in alveolar cells showed a similar pattern ofconcentrations during the experimental period. The MBFX concentrations both in ELF andalveolar cells were higher than in plasma. These results suggest that intramuscularlyinjected MBFX was well distributed in the bronchoalveolar region.