Carfilzomib Combined With Thalidomide and Low-dose Dexamethasone for Remission Induction and Consolidation in Newly Diagnosed Transplant Eligible Patients With Multiple Myeloma: 8 vs 4 Induction Cycles; the Carthadex Trial

摘要

Survival in patients with multiple myeloma (MM) has significantly improved during the last decades due to the introduction of novel therapies. In transplant-eligible patients with newly diagnosed multiple myeloma (NDMM) the depth of response following induction therapy is associated with a better progression free survival (PFS) and overall survival (OS). , However, it is currently unknown whether further improvement in response by increasing the number of induction cycles will translate in a better long-term outcome. Standard induction therapy consists of 4 to a maximum of six cycles of treatment including a proteasome inhibitor, an immunomodulatory drug and dexamethasone. The paradigm that improvement in response that in general is observed with increasing number of induction cycles will lead to a better outcome might be false. To the best of our knowledge, data from randomized clinical trials are lacking. Therefore, we here describe the outcome of a cohort study in which cohorts were treated with either 4 or 8 induction cycles of KTd.