Gold nanoparticle mediated radiation response among key cell components of the tumour microenvironment for the advancement of cancer nanotechnology

摘要

Normal and cancer associated fibroblasts in cancer therapeutics. ( ) In normal tissue, FBs have anti-tumourigenic properties that supress proliferation of the tumour. However, when CAFs are introduced, a largely pro-tumourigenic influence is now exerted on the tumour microenvironment, leading to growth and eventual metastasis. ( ) (i) Cells uptake GNPs at differing rates, which is directly related to the efficacy of the treatment. (ii) Cells are irradiated with a 2 Gy dose using a 6 MV linac. (iii) GNPs have been shown to have a radiosensitization effect on cancer cells, through improved formation of free radicals. ( ) Upon treatment with the dual combination of GNPs and radiation, the TME is more normalized and there is a reduction in tumour growth as well as invasive and migratory behaviour.