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SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45− Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome

机译：SARS-COV-2进入受体ACE2在非常小的CD45-造血和内皮细胞中表达并且响应于病毒尖状蛋白激活NLRP3炎症

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•Human VSELs and HSCs express ACE2 receptor for SARS-CoV2 entry.

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期刊名称 Nature Public Health Emergency Collection
作者
Mariusz Z. Ratajczak; Kamila Bujko; Andrzej Ciechanowicz; Kasia Sielatycka; Monika Cymer; Wojciech Marlicz; Magda Kucia;
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作者单位

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年(卷),期 -1(-1),-1
年度 -1
页码 -1
总页数 12
原文格式 PDF
正文语种
中图分类精神病学;
关键词
SARS-CoV-2; COVID19; Spike protein; ACE2; Nlrp3 inflammasome; VSELs; Hematopoietic stem cells; Cytokine storm; Pyroptosis;

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专利

1. A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2 [J] . StruckA.-W., AxmannM., PfefferleS., Antiviral Research . 2012,第3期

机译：SARS日冕病毒刺突蛋白受体结合结构域的六肽阻止病毒通过人类受体ACE2进入宿主细胞
2. Single-cell analysis of SARS-CoV-2 receptor ACE2 and spike protein priming expression of proteases in the human heart [J] . Liu Hanning, Gai Shujie, Wang Xiaoyi, Cardiovascular Research . 2020,第10期

机译：人体心脏蛋白酶SARS-COV-2受体ACE2和穗蛋白引发表达的单细胞分析
3. Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions [J] . Christopher J. Day, Benjamin Bailly, Patrice Guillon, MBio . 2021,第2期

机译：多学科方法鉴定与人ACE2或SARS-COV-2穗蛋白结合的化合物作为候选者，以阻断SARS-COV-2-ACE2受体相互作用
4. Bile salts activate endothelial NO synthase in sinusoidal endothelial cells of the liver via the G-protein coupled receptor TGR5 [C] . V. KEITEL, R. REINEHR, D. HAUSSINGER, International Bile Acid Meeting . 2007

机译：胆汁盐通过G蛋白偶联受体TGR5激活肝脏的正弦内皮细胞中内皮细胞中的内皮酶
5. Herpes simplex virus type I (HSV-1)-induced cell fusion: Influence of viral glycoprotein D alleles and cell surface expression of glycosaminoglycans on cell fusion mediated by HSV entry receptors HveA, HveB and HveC. [D] . Terry-Allison, Tracy Lynn. 1999

机译：I型单纯疱疹病毒（HSV-1）诱导的细胞融合：病毒糖蛋白D等位基因和糖胺聚糖的细胞表面表达对HSV进入受体HveA，HveB和HveC介导的细胞融合的影响。
6. Myxoma Virus Lacking the Pyrin-Like Protein M013 Is Sensed in Human Myeloid Cells by both NLRP3 and Multiple Toll-Like Receptors Which Independently Activate the Inflammasome and NF-κB Innate Response Pathways [O] . Masmudur M. Rahman, Grant McFadden 2011

机译：NLRP3和多个Toll-like受体在人类髓样细胞中都检测到缺乏类似类蛋白M013的粘液瘤病毒后者独立激活炎性体和NF-κB先天性反应途径
7. Myxoma Virus Lacking the Pyrin-Like Protein M013 Is Sensed in Human Myeloid Cells by both NLRP3 and Multiple Toll-Like Receptors, Which Independently Activate the Inflammasome and NF-κB Innate Response Pathways▿ [O] . Rahman, Masmudur M., McFadden, Grant 2011

机译：NLRP3和多个Toll-like受体在人类髓样细胞中均检测到缺乏类似类蛋白M013的粘液瘤病毒，后者独立激活炎性体和NF-κB先天性反应途径。

SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45− Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome

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