Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings

摘要

Effect of tregitope treatment on foetal death rates, numbers of viable and resorbed embryos, total implantation sites and cytokine levels in a murine abortion-prone pregnancy model. Effect of tregitope injection on foetal death rate and numbers of viable, resorbed embryos and total implantation sites evaluated at the 14 day of pregnancy. Effect of tregitope injection on TGFβ1 concentrations in serum on the 3 and 14 days of pregnancy. The data were analysed by the Kruskal-Wallis test (non-normal distribution) with Dunn’s multiple comparison post-hoc test (P