Lipopolysaccharide induced vascular smooth muscle cells proliferation: A new potential therapeutic target for proliferative vascular diseases

摘要

Vascular smooth muscle cells ( s) proliferation is involved in vascular atherosclerosis and restenosis. Recent studies have demonstrated that lipopolysaccharide ( ) promotes s proliferation, but the signalling pathways which are involved are not completely understood. The purpose of this review was to summarize the existing knowledge of the role and molecular mechanisms involved in controlling s proliferation stimulated by and mediated by toll‐like receptor 4 ( 4) signalling pathways. Moreover, the potential inhibitors of 4 signalling for s proliferation in proliferative vascular diseases are discussed.