Relapse-Fated Subclones: Finding the Needle in the Haystack

摘要

In a recent paper, Stephanie Dobson et al identified rare relapse-fated subclones in B-ALL and showed that they possess an intrinsic drug tolerance as well as metabolic and stemness signatures. The identification of these subclones and associated pathways will be instrumental to target relapse-fated cells, thereby preventing their full evolution into relapse clones.