Analysis of selected genes associated with cardiomyopathy by next‐generation sequencing

摘要

As the leading cause of congestive heart failure, cardiomyopathy represents a heterogenous group of heart muscle disorders. Despite considerable progress being made in the genetic diagnosis of cardiomyopathy by detection of the mutations in the most prevalent cardiomyopathy genes, the cause remains unsolved in many patients. High‐throughput mutation screening in the disease genes for cardiomyopathy is now possible because of using target enrichment followed by next‐generation sequencing. The aim of the study was to analyze a panel of genes associated with dilated or hypertrophic cardiomyopathy based on previously published results in order to identify the subjects at risk.