AdipoQ T45 G and G276 T Polymorphisms and Susceptibility to Nonalcoholic Fatty Liver Disease Among Asian Populations: A Meta‐Analysis and Meta‐Regression

摘要

Adiponectin (AdipoQ) is an adipose‐derived plasma protein that plays an important role in hepatic lipoprotein–lipid metabolism. Emerging evidence have shown that two common polymorphisms (T45 G and G276 T) in the gene may contribute to increasing susceptibility to nonalcoholic fatty liver disease (NAFLD); however individually published studies show inconclusive results. This meta‐analysis aimed to derive a more precise estimation of the association of T45 G (rs2241766 T>G) and G276 T (rs1501299 G>T) polymorphisms with NAFLD risk.