Comparative Evaluation of Serum C‐Reactive Protein (CRP) Levels in the Different Histological Subtypes of Esophageal Cancer (Squamous Cell Carcinoma and Adenocarcinoma of Esophagus)

摘要

Elevated ‐reactive protein ( ) levels have been found in patients with several malignancies. The aim of the present study was to analyze the diagnostic and prognostic values of levels measurement in esophageal cancer ( ) patients in relation to its different histological subtypes (squamous cell carcinoma— and adenocarcinoma— of esophagus) and compared them with classic tumor markers—carcinoembryonic antigen ( ) and squamous cell cancer antigen ( ‐ g). The diagnostic sensitivity, specificity, and the areas under receiver operating characteristic curves ( ) for all the proteins tested were defined. Serum levels were statistically higher in , , and patients compared to healthy subjects and significantly increased in and patients with the presence of lymph node and distant metastases. The percentage of elevated results in all the analyzed subgroups ( , , and ) was higher than and ‐ g, similarly as for in comparison to ‐ g. Serum level was a significant predictor of and patients’ survival in univariate analysis. In conclusion, these results indicate that can be used as an adjunct in evaluating the tumor markers— and ‐ g and may improve the clinical diagnosis and follow‐up of patients, especially for subgroup.