Analysis of urinary albumin transferrin N‐acetylβ‐d‐glucosaminidase and β2‐microglobulin in patients with impaired glucose tolerance

摘要

We investigated the changes in urinary albumin and urinary transferrin as glomerular proteins, and in urinary ‐acetyl‐β‐ ‐glucosaminidase and urinary β ‐microglobulin as tubular proteins, in patients with impaired glucose tolerance. We attempted to compare the proteins of normal subjects to those of diabetics with pre‐nephropathy. Transferrin and ‐acetyl‐β‐ ‐glucosaminidase levels were significantly increased in patients with impaired glucose tolerance, while albumin and β ‐microglobulin levels were only slightly increased. In addition, there was no significant difference in transferrin levels between patients with impaired glucose tolerance and type 2 diabetics with pre‐nephropathy.