Systematic Multiomic Analysis of Ly75 Gene Expression and Its Prognostic Value through the Infiltration of Natural Killer (NK) Cells in Skin Cutaneous Melanoma

摘要

(also known as DEC-205 or CD205) is expressed in immune cells and cancers and involved in tumor immunity. However, clinical relevance of expression in skin cutaneous melanoma (SKCM) have not been comprehensively studied. This study analyzed the correlation between mRNA expression and patient survival using systematic multiomic analysis tools. mRNA expression level was significantly lower in SKCM tissues than in normal tissues. Survival analysis showed that expression significantly correlated with good patient survival. To determine possible mechanisms, the association between expression and immune cell infiltration was analyzed. expression was positively correlated with various infiltrated immune cells, particularly with natural killer (NK) cell infiltration and activation in SKCM. Moreover, analysis of -co-altered gene expression revealed that (CD45) was most significantly correlated with . Gene ontology analysis of -co-altered genes indicated the relation to lymphocyte activation, including NK cell activation. Overall, our study provides the first clinical evidence that expression is significantly associated with melanoma patient survival and NK cell infiltration, suggesting that could be a useful prognostic factor.