Potential therapeutic options for coronavirus disease 2019: using knowledge of past outbreaks to guide future treatment

摘要

In December 2019, initial cases of the novel coronavirus (2019-nCoV) infection, termed coronavirus disease 2019 (COVID-19), were first reported in Wuhan, China. In humans, infections with the human coronavirus 229E, OC43, NL63, and HKU1 usually result in mild, self-limiting upper respiratory tract infections. However, other variants have rapid transmission rates and can cause severe respiratory syndrome and death. These variants include severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the current 2019-nCoV.