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Inhibition of hepatitis C virus replication by Monascus pigment derivatives that interfere with viral RNA polymerase activity and the mevalonate biosynthesis pathway

机译：红曲霉色素衍生物抑制丙型肝炎病毒复制干扰病毒RNA聚合酶活性和甲羟戊酸酯生物合成途径

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摘要

Hepatitis C virus (HCV) infection causes chronic liver disease and is a major public health problem worldwide. The aim of this study was to evaluate the potential of pigment derivatives, which were derived from a microbial secondary metabolite synthesized from polyketides by spp., as HCV antiviral agents.

机译：丙型肝炎病毒（HCV）感染会导致慢性肝病，并且是全球范围内的主要公共卫生问题。这项研究的目的是评估颜料衍生物的潜力，这些颜料衍生物是由聚酮化合物经spp。合成的微生物次生代谢产物作为HCV抗病毒剂。

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期刊名称 Journal of Antimicrobial Chemotherapy
作者
Ji-Min Sun; Seong-Jun Kim; Geon-Woo Kim; Jin-Kyu Rhee; Nam Doo Kim; Heeyong Jung; Jungae Jeun; Seung-Hoon Lee; Seung Hyun Han; Chul Soo Shin; Jong-Won Oh;
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作者单位

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年(卷),期 -1(67),1
年度 -1
页码 -1
总页数 10
原文格式 PDF
正文语种
中图分类药学;微生物学;病毒传染病;
关键词
HCV; RNA-dependent RNA polymerase; HMG-CoA reductase;

机译：HCV;RNA依赖性RNA聚合酶;HMG-CoA还原酶;

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专利

1. Inhibition of hepatitis C virus replication by Monascus pigment derivatives that interfere with viral RNA polymerase activity and the mevalonate biosynthesis pathway [J] . Ji-Min Sun12 Seong-Jun Kim1 Geon-Woo Kim12 Jin-Kyu Rhee1 Nam Doo Kim3 Heeyong Jung1 Jungae Jeun1 Seung-Hoon Lee12 Seung Hyun Han4 Chul Soo Shin1 and Jong-Won Oh12* Journal of Antimicrobial Chemotherapy . 2012,第1期

机译：红曲霉色素衍生物抑制丙型肝炎病毒复制，干扰病毒RNA聚合酶活性和甲羟戊酸生物合成途径
2. Inhibition of hepatitis C virus replication by Monascus pigment derivatives that interfere with viral RNA polymerase activity and the mevalonate biosynthesis pathway. [J] . Ji-Min Sun, Seong-Jun Kim, Geon-Woo Kim, The Journal of Antimicrobial Chemotherapy . 2012,第1期

机译：红曲霉色素衍生物抑制丙型肝炎病毒复制，干扰病毒RNA聚合酶活性和甲羟戊酸酯生物合成途径。
3. Efficient inhibition of hepatitis B virus replication by small interfering RNAs targeted to the viral X gene in mice. [J] . Shin D, Kim SI, Kim M, Virus Research: An International Journal of Molecular and Cellular Virology . 2006,第2期

机译：通过靶向小鼠中病毒X基因的小干扰RNA有效抑制乙型肝炎病毒复制。
4. Simultaneous extraction of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) RNA with the M1000 apparatus does not impair the measurement of the viral load of both viruses when tested by using the LCx PCR system [C] . T. Bourlet, S. Thamm, S. Pillet, European Congress of Virology . 2004

机译：通过使用LCX PCR系统测试，同时提取人免疫缺陷病毒类型1（HIV-1）和丙型肝炎病毒（HCV）RNA，不会损害两种病毒的病毒载量的测量
5. In vitro studies of the hepatitis C virus (HCV) RNA dependent RNA polymerase NS5B: The impact of the NS5A protein on replication [D] . Quezada, Elizabeth Margarita 2008

机译：丙型肝炎病毒（HCV）RNA依赖性RNA聚合酶NS5B的体外研究：NS5A蛋白对复制的影响
6. Zinc Salts Block Hepatitis E Virus Replication by Inhibiting the Activity of Viral RNA-Dependent RNA Polymerase [O] . Nidhi Kaushik, Chandru Subramani, Saumya Anang, 2017

机译：锌盐通过抑制病毒依赖RNA的RNA聚合酶的活性阻止戊型肝炎病毒复制。
7. Mutations in NS5B Polymerase of Hepatitis C Virus: Impacts on in Vitro Enzymatic Activity and Viral RNA Replication in the Subgenomic Replicon Cell Culture [O] . Cheney I.Wayne, Naim Suhaila, Lai Vicky C.H., 2002

机译：丙型肝炎病毒NS5B聚合酶中的突变：对亚基因组复制子细胞培养中体外酶活性和病毒RNA复制的影响。

Inhibition of hepatitis C virus replication by Monascus pigment derivatives that interfere with viral RNA polymerase activity and the mevalonate biosynthesis pathway

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