Long-term probiotic intervention mitigates memory dysfunction through a novel H3K27me3-based mechanism in lead-exposed rats

摘要

– MWM tests assessing capacities of rats to be trained to find the hidden platform (  = 10). Latency of rats to find the platform was recorded and analyzed during the training days ( ). On the test day, based on their respective moving tracks ( ), number of times crossing the hidden platform ( ) and distance traveled in the target quadrant ( ) were counted at PND 61. The total distance traveled was also recorded to evaluate the locomotor movement of rats ( ). Y-maze test assessing capacities of rats to perform the spontaneous alteration (  = 10). Spontaneous alteration percentages of each group, as well as their respective moving tracks are shown. Ctrl non-treated rats, Pb lead-treated rats, Pb+prob lead and probiotics-treated rats, prob probiotics-treated rats. The data are represented as mean ± SEM; ***  p a, repeated-measures ANOVA was performed and asterisk (*) refers to the significance of differences between the Pb and Ctrl groups on the indicated training day.