Stress impacts sensory variability through cortical sensory activity motifs

摘要

A representative craniotomy with VSD incubation and the mesoscale field of view alongside a schematic brain. Standardized stimulation protocols yield sensory VSD responses with millisecond timescale resolution. A montage of the correlation time course between spontaneous cortical activity and sensory derived templates. ( – ) Examples of sensory-evoked templates and spontaneous sensory motifs ‘matches’ from two animals. The frequency of motifs in  = 53 animals recorded the anaesthetized sate is associated with the frequency of motifs during states of quiet wakefulness for forelimb ( (1,53) = 23.01,  = 1.4 × 10 , -corrected = 4.2 × 10 ), hindlimb ( (1,53) = 10.43,  = 0.0022, -corrected = 0.0066), and whisker ( (1,50) = 6.22,  = 0.016, -corrected = 0.048). Each point represents an individual animal and the frequency of spontaneous motifs identified over 50,005 frames of spontaneous activity in both conditions.