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Prevention of multiple system atrophy using human bone marrow-derived mesenchymal stem cells by reducing polyamine and cholesterol-induced neural damages

机译:使用人骨髓源间充质干细胞通过减少多胺和胆固醇引起的神经损伤来预防多系统萎缩

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摘要

Mesenchymal stem cell (MSC) transplantation ameliorates double-toxin-induced behavior disorders. The performance on the rotarod test was impaired following the double-toxin injection. However, the impairment was ameliorated in the double-toxin-injected MSC-transplanted group ( ). Double-toxin-induced bradykinesia was ameliorated in the double-toxin-injected MSC-transplanted group ( ). The stride length of the forelimb ( ) and hindlimb ( ) was increased to a greater extent following MSC treatment in the double-toxin injection group. Values are presented as mean ± standard deviation of 10 rats. *  P
机译:间充质干细胞(MSC)移植改善双毒素诱导的行为障碍。注射双毒素后,旋转脚架测试的性能受损。但是,双毒素注射的MSC移植组()的损伤得以改善。双毒素注射的MSC移植组改善了双毒素诱导的运动迟缓()。在双毒素注射组中,MSC治疗后前肢()和后肢()的步幅增加了更多。数值表示为10只大鼠的平均值±标准偏差。 * P

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