S115. NOVEL TECHNIQUES FOR THERAPEUTIC DRUG MONITORING FOR CLOZAPINE LEVELS

摘要

Clozapine is an effective antipsychotic for treatment-resistant schizophrenia for which serum levels could guide therapy decisions. It is underutilized because it requires venous draws and several-day determination time with high performance liquid chromatography-tandem mass spectrometry (LC/MS-MS). This project evaluates if clozapine measured with a novel immunoassay technology, which could be developed into a fingerstick test, correlate with LC/MS-MS. This project also assesses the impact of demographic and clinical variables on assay results.