F92. EFFECT OF CLOZAPINE ON FRONTAL ACTIVITY IN TREATMENT RESISTANT SCHIZOPHRENIA - A PROSPECTIVE STUDY USING FUNCTIONAL NEAR INFRARED SPECTROSCOPY

摘要

Clozapine is the only antipsychotic proven to be of definitive higher efficacy than any other drug in patients with treatment resistant schizophrenia. In particular, it is the first line treatment for treatment-resistant schizophrenia. There is evidence that abnormalities in regional blood flow and perfusion are associated with impaired brain functions in patients with schizophrenia. A few studies have reported the hemodynamic changes in antipsychotic response. However, conflicting observations are reported with regards to the impact of clozapine on prefrontal neurohemodynamics (i.e. both increase as well as decreased activations have been described). The current study aimed at evaluating the changes in neurohemodynamic response to n-Back task using functional near infrared spectroscopy (fNIRS) in patients on clozapine.