T71. INVESTIGATING NEURAL MECHANISMS OF PROACTIVE AND REACTIVE CONTROL IN PSYCHOTIC DISORDERS WITH THE DOT PATTERN EXPECTANCY TASK

摘要

The dot pattern expectancy (DPX) task is previously validated for cognitive control deficits in psychotic disorders. Patients with schizophrenia commit more errors as well as show less activation in bilateral prefrontal cortex during proactive control in the DPX task. Recent neural recordings in rhesus macaques indicate that proactive and reactive control processes in the DPX task engaged the same neurons in the prefrontal cortex. However, it is not clear if the overlap between these two mechanisms can be observed in human blood-oxygen-level dependent signals. Further, the role of these dual mechanism regions in the cognitive control deficits of patients with psychotic disorders remains unclear.