Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized Placebo-Controlled Study

摘要

Specific probiotic strains can alleviate the gastrointestinal (GI) symptoms and psychiatric comorbidities of irritable bowel syndrome (IBS). In this randomized, double-blind, placebo-controlled study, the efficacy of HA-196 ( ) and R0175 ( ) in reducing the GI and psychological symptoms of IBS was evaluated in 251 adults with either constipation (IBS-C), diarrhea (IBS-D), or mixed-pattern (IBS-M). Following a 2-week run-in period, participants were randomized to one of three interventions: ( = 84), ( = 83) or placebo ( = 81). IBS symptoms, stool frequency and consistency and quality of life were assessed by questionnaires. The differences from baseline in the severity of IBS symptoms at 4 and 8 weeks were similar between groups. Participants in this study were classified, after randomization, into subtypes according to Rome III. Within the group, complete spontaneous and spontaneous bowel movement frequency increased in participants with IBS-C ( = 10) after 8 weeks of supplementation (both < 0.05) and decreased in participants with IBS-D ( = 10, = 0.013). Both and supplementation improved the quality of life in emotional well-being and social functioning compared with baseline (all < 0.05). In conclusion, and may reduce GI symptom severity and improve the psychological well-being of individuals with certain IBS subtypes.