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Circ-OXCT1 Suppresses Gastric Cancer EMT and Metastasis by Attenuating TGF-β Pathway Through the Circ-OXCT1/miR-136/SMAD4 Axis

机译：Circ-OXCT1通过减弱通过Circ-OXCT1 / miR-136 / SMAD4轴的TGF-β途径抑制胃癌EMT和转移

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摘要

Circular RNAs (circRNAs) have been proven to play important roles in tumorigenesis. However, the mechanism by which circRNAs act on gastric cancer (GC) through epithelial-to-mesenchymal transition (EMT) is unclear. In this study, we identified circ-OXCT1 and elucidated its function on EMT in GC.

机译：环状RNA（circRNA）已被证明在肿瘤发生中起重要作用。然而，circRNA通过上皮-间充质转化（EMT）作用于胃癌（GC）的机制尚不清楚。在这项研究中，我们鉴定了circ-OXCT1并阐明了其在GC中对EMT的作用。

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期刊名称 OncoTargets and therapy
作者
Jianjun Liu; Xinglong Dai; Xiong Guo; Anqi Cheng; Sandrie Mariella Mac; Ziwei Wang;
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作者单位

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年(卷),期 2020(13),-1
年度 2020
页码 -1
总页数 12
原文格式 PDF
正文语种
中图分类应用微生物学;肿瘤学;
关键词
gastric cancer; GC; circ-OXCT1; miR-136; SMAD4; EMT;

机译：胃癌;GC;circ-OXCT1;miR-136;SMAD4;EMT;

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专利

1. Circ-OXCT1 Suppresses Gastric Cancer EMT and Metastasis by Attenuating TGF-β Pathway Through the Circ-OXCT1/miR-136/SMAD4 Axis [J] . Jianjun Liu, Xinglong Dai, Xiong Guo, OncoTargets and therapy . 2020,第2期

机译：循环氧基氧化物1通过循环氧化TGF-β途径抑制胃癌EMT和转移，通过循环氧化物1 / miR-136 / smad4轴衰减
2. SALL4 activates TGF-β/SMAD signaling pathway to induce EMT and promote gastric cancer metastasis [J] . Xu Zhang, Peng Zhang, Meng Shao, Cancer Management and Research . 2018,第2016期

机译：SALL4激活TGF-β/ SMAD信号通路以诱导EMT并促进胃癌转移
3. Long Intergenic Non-Protein Coding RNA 1089 Suppresses Cell Proliferation and Metastasis in Gastric Cancer by Regulating miRNA-27a-3p/Epithelial–Mesenchymal Transition (EMT) Axis [J] . Feng Yang, Xiaoting Chen, Xiyao Li, Cancer Management and Research . 2020,第4期

机译：通过调节miRNA-27A-3P /上皮 - 间充质转换（EMT）轴来抑制胃癌中细胞增殖和转移的长性非蛋白质编码RNA 1089
4. Prophylaxis and Treatment of Advanced Gastric Cancer with Peritoneal Metastasis with Intraperitoneal(I.P.) Administration of Liposome-Carboplatin(Lipo-CBDCA) and Its Clinical Trial in Peritoneal Carcinomatosis(P.C.). [C] . Mizuno I., Yotsuyanagi T., Ishida M., International Gastric Cancer Congress . 2011

机译：腹膜内（I.P，I.P）对腹膜转移的预防和治疗晚期胃癌（I.P。）脂质体 - 卡铂（Lipo-CBDCA）的施用及其在腹膜癌症中的临床试验（P.C。）。
5. The Role of HIF-1α and TGF-β Signaling in Breast Cancer Bone Metastasis [D] . Dunn, Lauren Kingsley 2009

机译：HIF-1α和TGF-β信号在乳腺癌骨转移中的作用
6. Long Intergenic Non-Protein Coding RNA 1089 Suppresses Cell Proliferation and Metastasis in Gastric Cancer by Regulating miRNA-27a-3p/Epithelial–Mesenchymal Transition (EMT) Axis [O] . Feng Yang, Xiaoting Chen, Xiyao Li, 2020

机译：通过调节miRNA-27A-3P /上皮 - 间充质转换（EMT）轴来抑制胃癌中细胞增殖和转移的长性非蛋白质编码RNA 1089
7. >Circ-OXCT1 Suppresses Gastric Cancer EMT and Metastasis by Attenuating TGF-β Pathway Through the Circ-OXCT1/miR-136/SMAD4 Axis [O] . Jianjun Liu, Xinglong Dai, Xiong Guo, 2020

机译：>循环氧基氧化物1通过通过循环氧化镍/ miR-136 / smad4轴衰减TGF-β通路来抑制胃癌EMT和转移。
8. BRMS1 Suppresses Breast Cancer Metastasis to Bone via Its Regulation of microRNA-125b and Downstream Attenuation of TNF-Alpha and HER2 Signaling Pathways [R] . Khotskaya, Y B 2014

机译：BRms1通过调节microRNa-125b和TNF-α和HER2信号通路的下游衰减抑制乳腺癌向骨转移

Circ-OXCT1 Suppresses Gastric Cancer EMT and Metastasis by Attenuating TGF-β Pathway Through the Circ-OXCT1/miR-136/SMAD4 Axis

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