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Histamine H3 Receptor Promotes Cell Survival via Regulating PKA/CREB/CDKN1A Signal Pathway in Hepatocellular Carcinoma

机译：组胺H3受体通过调节肝细胞癌中的PKA / CREB / CDKN1A信号通路来促进细胞存活

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The histamine H3 receptor (HRH3) is mainly expressed in areas of the brain involved in the regulation of the release of various neurotransmitters. Recent studies have shown that HRH3 expression is increased in several types of carcinomas. However, the functional roles and underlying molecular mechanism by which HRH3 regulates cell survival in hepatocellular carcinoma (HCC) remain unknown.

机译：组胺H3受体（HRH3）主要在涉及调节各种神经递质释放的大脑区域中表达。最近的研究表明，在几种类型的癌症中，HRH3表达增加。但是，HRH3调节肝细胞癌（HCC）细胞存活的功能作用和潜在的分子机制仍然未知。

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期刊名称 OncoTargets and therapy
作者
Chunle Zhang; Yang Yu; Liang Ma; Ping Fu;
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作者单位

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年(卷),期 2020(13),-1
年度 2020
页码 -1
总页数 12
原文格式 PDF
正文语种
中图分类应用微生物学;肿瘤学;
关键词
HRH3; CDKN1A; cell survival; hepatocellular carcinoma;

机译：HRH3;CDKN1A;细胞存活;肝细胞癌;

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专利

1. Histamine H3 Receptor Promotes Cell Survival via Regulating PKA/CREB/CDKN1A Signal Pathway in Hepatocellular Carcinoma [J] . Chunle Zhang, Yang Yu, Liang Ma, OncoTargets and therapy . 2020,第2期

机译：组胺H3受体通过调节PKA / CREB / CDKN1A信号途径在肝细胞癌中促进细胞存活
2. Prostaglandin E-2 promotes the cell growth and invasive ability of hepatocellular carcinoma cells by upregulating c-Myc expression via EP4 receptor and the PKA signaling pathway [J] . Xia Shukai, Ma Juan, Bai Xiaoming, Oncology reports . 2014,第4期

机译：前列腺素E-2通过通过EP4受体和PKA信号通路上调c-Myc表达来促进肝癌细胞的生长和侵袭能力
3. Upregulated histamine receptor H3 promotes tumor growth and metastasis in hepatocellular carcinoma [J] . Yu Deliang, Zhao Jing, Wang Yuhong, Oncology reports . 2019,第6期

机译：上调的组胺受体H3促进肝细胞癌中的肿瘤生长和转移
4. Towards a Serum-free Culture Medium: Identifying Human Growth Receptors and Signaling Pathways that regulate Cell Proliferation in Human Mesenchymal Stem Cells (MSCs) [C] . Nicholas Xue Wei Tan, Felicia Soo Lee Ng, Vivek Tanavde International Conference on Bioinformatics and Computational Biology . 2007

机译：朝向无血清培养基：鉴定人生长受体和调节人间充质干细胞中细胞增殖的信号通路（MSC）
5. Analysis of the Role of Glucagon in Hepatocellular Carcinoma Cell Growth, Invasion, and Migration and the Regulation of Glucagon Receptor Signaling. [D] . Nguyen, Amy C. 2011

机译：胰高血糖素在肝细胞癌细胞生长，侵袭和迁移中的作用分析以及胰高血糖素受体信号传导的调控。
6. The fibroblast growth factor receptor 2-mediated extracellular signal-regulated kinase 1/2 signaling pathway plays is important in regulating excision repair cross-complementary gene 1 expression in hepatocellular carcinoma [O] . GANG CHEN, HONG QIU, SHANDONG KE, -1

机译：成纤维细胞生长因子受体2介导的细胞外信号调节激酶1/2信号通路在调节肝癌切除修复交叉互补基因1表达中起重要作用
7. >Histamine H3 Receptor Promotes Cell Survival via Regulating PKA/CREB/CDKN1A Signal Pathway in Hepatocellular Carcinoma [O] . Chunle Zhang, Yang Yu, Liang Ma, 2020

机译：>组胺H3受体通过调节肝细胞癌中的PKA / CREB / CDKN1A信号途径来促进细胞存活

Histamine H3 Receptor Promotes Cell Survival via Regulating PKA/CREB/CDKN1A Signal Pathway in Hepatocellular Carcinoma

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