The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change

摘要

A GWAS for baseline-adjusted difference of natural log-transformed LDL-C levels yielded six significant loci ( ), whereas a GWAS of baseline-unadjusted statin-induced percent LDL-C lowering yielded three loci that met genome-wide significance ( ). Consistent with the impact of baseline-adjustment on results, baseline-unadjusted difference of natural log-transformed LDL-C levels ( ) and baseline-adjusted statin-induced percent LDL-C lowering ( ) yielded three and six genome-wide significant loci, respectively. All tests were two-sided.