Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro

摘要

Microfluidic devices with FB titration cultured for 7 days. EC concentrations were 1.0 × 10 cells per ml and FBs ranged from 5.0 × 10 to 5.0 × 10 . Graphs quantify vessel density, diameter, and anastomoses within microfluidic devices. Statistically significant differences between groups are indicated by asterisks (*). Long-term culture of microfluidic devices with 1.0 × 10 ECFCs per ml and 2.5 × 10 per ml FBs. Graphs quantify vessel density and diameters over the long time-course. Scale bars of tile images are 250 µm.