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CONTROLLABLE FORMATION OF MICROVASCULAR NETWORKS USING SACRIFICIAL MICROFIBER TEMPLATES
CONTROLLABLE FORMATION OF MICROVASCULAR NETWORKS USING SACRIFICIAL MICROFIBER TEMPLATES
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机译:使用牺牲性超细纤维模板可控地形成微血管网络
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摘要
The present disclosure relates to fabricating sacrificial microfiber templates from any biocompatible and resorbable materials depending on the time needed for dissolving the microfiber template to free the endothelial tube with open lumen. Microfiber networks with distinct patterns and defined diameters initially serve as a template to support the growth of vascular cells (endothelial cells or their progenitor cells, or combined with mural cells such as pericytes) and then dissolve to form an empty endothelium lumen. The incorporation of sacrificial microfiber networks encapsulated with vascular cells into 3D cell-rich constructs allows for the creation of various vascularized tissues.
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