Acute levodopa dosing around-the-clock ameliorates REM sleep without atonia in hemiparkinsonian rats

摘要

Comparison of sleep-wake stage classification between polysomnography and the behavior-based criteria and between two separate blinded raters in control rats. In control rats (  = 10), there was good agreement between the average of the raters (Average of Scorer 1 and Scorer 2) and polysomnography (PSG) indicating the high face validity of the behavior-based criteria for classification of all sleep-wake stages (Wake, NREM, and REM). Comparisons between raters (Scorer 1 vs. Scorer 2) also showed a good level of agreement indicating high inter-rater reliability of the behavior-based criteria. A 1-h graphed sleep profile comparing classification between the raters and PSG also showed close matches in all sleep-wake stages, with all REM periods correctly identified by the raters.