A powerful microbial group association test based on the higher criticism analysis for sparse microbial association signals

摘要

Empirical type I error rates at the significance level of 5% for the individual (i.e., uHC ’s and wHC ’s for ∈ {1, 3, 5, 7, 9}) and omnibus (i.e., uHC , wHC , and MiHC) higher criticism tests, the Simes test, and the other competing tests (i.e., aMiAD, aMiSPU, and OMiRKAT)